Cardioprotective effect of polyamine spermidine
نویسندگان
چکیده
منابع مشابه
Spermidine Promotes Cardioprotective Autophagy.
Background Our population is aging—shifting in distribution toward older age—at an unprecedented pace. Based on US population reports, the percentage of people aged >65 years is estimated to increase from 13.4% in 2012 to 19.3% in 2030. And as aging is the greatest risk factor for major life-threatening disorders, including cardiovascular and neurodegenerative diseases, metabolic syndromes, and...
متن کاملEffect of Spermidine Analogues on Cell Growth of Escherichia coli Polyamine Requiring Mutant MA261
The effects of spermidine analogues [norspermidine (NSPD, 33), spermidine (SPD, 34), homospermidine (HSPD, 44) and aminopropylcadaverine (APCAD, 35)] on cell growth were studied using Escherichia coli polyamine-requiring mutant MA261. Cell growth was compared at 32°C, 37°C, and 42°C. All four analogues were taken up mainly by the PotABCD spermidine-preferential uptake system. The degree of stim...
متن کاملEffect of Polyamine Structure on Growth Stimulation and Spermine and Spermidine Content of Lactic Acid Bacteria.
Guirard, Beverly M. (University of California, Berkeley), and Esmond E. Snell. Effect of polyamine structure on growth and spermine and spermidine content of lactic acid bacteria. J. Bacteriol. 88:72-80. 1964.-Growth from small inocula of six species of lactobacilli was stimulated by addition of spermine or spermidine to a defined medium; none of four streptococcal species showed this effect. L...
متن کاملPolyamine-dependent regulation of spermidine-spermine N1-acetyltransferase mRNA translation.
Spermidine-spermine N(1)-acetyltransferase (SSAT) is induced in response to an elevation in intracellular polyamine pools. The increased enzyme activity is the result of an increase in gene transcription, mRNA translation, and protein stability. Induction of SSAT by polyamine analogues can lead to intracellular polyamine depletion and apoptosis. The mechanism by which polyamines alter the trans...
متن کاملPolyamine regulation of heat-shock-induced spermidine N1-acetyltransferase activity.
The enzyme spermidine/spermine N1-acetyltransferase (N1-SAT) is rapidly induced by heat shock in CHO and A549 cells, with activity declining by 24 h. Depletion of intracellular polyamines by alpha-difluoromethylornithine, an inhibitor of ornithine decarboxylase, blocks this induction. Re-addition of putrescine to these cultures restores the response to heat shock, with a concomitant increase in...
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ژورنال
عنوان ژورنال: The American Journal of Clinical Nutrition
سال: 2018
ISSN: 0002-9165,1938-3207
DOI: 10.1093/ajcn/nqy221